Crystalline forms of a pyridinyl-sulfonamide and their use as endothelin receptor antagonists
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United States of America Patent
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Jul 22, 2008
Grant Date -
Jul 26, 2007
app pub date -
May 12, 2005
filing date -
May 13, 2004
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Abstract
Crystalline forms A and B of 5-methyl-pyridine-2-sulfonic acid [6-methoxy-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide of formula (I) are described, whereby form B is the most stable form. 5-methyl-pyridine-2-sulfonic acid [6-methoxy-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide also forms solvates with, for example, ethanol, acetone, tetrahydrofuran, methanol, isopropanol, 2-butanone and dichloromethane.
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