Vectors with modified protease-dependent tropism
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United States of America Patent
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Jul 22, 2008
Grant Date -
Oct 6, 2005
app pub date -
Apr 30, 2003
filing date -
Apr 30, 2002
priority date (Note) -
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Abstract
The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo.
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