Trans-splicing mediated photodynamic therapy
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United States of America Patent
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Jul 15, 2008
Grant Date -
Jul 8, 2004
app pub date -
Sep 9, 2003
filing date -
Feb 25, 2002
priority date (Note) -
Expired
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Abstract
The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) expressed within a cell and mediate a trans-splicing reaction resulting in the generation of a novel chimeric mRNA molecule (chimeric mRNA) capable of encoding a light producing protein or enzyme. Cell death is further mediated by the presence of a photosensitizer which upon photoactivation produces cytotoxicity.
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