System and method for obtaining and maintaining high-resistance seals in patch clamp recordings
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United States of America Patent
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Jun 24, 2008
Grant Date -
Jun 10, 2004
app pub date -
Aug 20, 2003
filing date -
Aug 21, 2002
priority date (Note) -
Expired
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Abstract
The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a whole cell and the cell-contact surface of a patch clamp micropipette, maximizing the efficiency of a whole cell patch clamp recording.
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