Sesquiterpenoid derivatives having adipocyte differentiation inhibitory effect
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United States of America Patent
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Jun 17, 2008
Grant Date -
Mar 3, 2005
app pub date -
Aug 9, 2002
filing date -
Aug 15, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The objective of the present invention is to identify compounds having an inhibitory effect on adipocyte differentiation, and to provide pharmaceutical compositions and food compositions for prevention, improvement, or treatment of obesity or obesity related diseases. By enthusiastically studying natural products that inhibit the differentiation induction of adipocyte precursors into adipocytes, sesquiterpenoid derivatives, which are extracts from a Compositae plant, Calea, growing in Central and South America, were demonstrated to have an excellent inhibitory effect on adipocyte differentiation induction. Calea extract or the sesquiterpenoid derivatives are expected to be used in pharmaceutical compositions and food compositions for prevention, improvement, or treatment of obesity related diseases.
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