Method of making tetrapeptide derivative TZT-1027 crystal
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United States of America Patent
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Jun 10, 2008
Grant Date -
Dec 1, 2005
app pub date -
Jul 14, 2005
filing date -
Sep 20, 2001
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Abstract
The invention provides crystals of N.sup.2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1--methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[-(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.
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