Bioluminescent protease assay with modified aminoluciferin or derivatives thereof
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United States of America Patent
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Jun 10, 2008
Grant Date -
Aug 17, 2006
app pub date -
Feb 2, 2006
filing date -
Feb 1, 2002
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Abstract
A sensitive bioluminescent assay to detect proteases, including caspases and proteases that specifically cleave a peptide substrate having aspartate, is provided. In one embodiment, the assay employs an aminoluciferin or a carboxy-terminal protected derivative thereof covalently linked via a peptide bond to a substrate for a caspase or an aminoluciferin or a carboxy-terminal protected derivative thereof covalently linked via a peptide bond to a peptide substrate comprising aspartate that is specifically cleaved by a protease specific for the substrate.
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