DNA encoding a human imidazoline receptor and ligand binding assay employing same
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United States of America Patent
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Jun 10, 2008
Grant Date -
Dec 4, 2003
app pub date -
Apr 24, 2003
filing date -
Mar 1, 1996
priority date (Note) -
Expired
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Abstract
A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represent the first in a novel family of receptor proteins. Methods of cloning the cDNA and expressing the imidazoline receptor in a host cell are described. Also, a screening method for identifying drugs that interact with the imidazoline receptor is described.
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