Tetrahydro-naphthalene derivatives
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United States of America Patent
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Jun 3, 2008
Grant Date -
Jun 15, 2006
app pub date -
Nov 28, 2003
filing date -
Dec 6, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. They have the general formula (I) ##STR00001## in which R.sup.1 represents hydrogen or C.sub.1-6 alkyl, and X represents --N(H)Y.sup.1, --(H)--C.sub.1-6 alkyleneY.sup.1, biphenyl or C.sub.1-6 alkyl substituted by biphenyl, and the group Y.sup.1 is an optionally substituted biphenyl. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonists and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontinence, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
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