Immunostimulatory oligonucleotides and uses thereof
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Jun 3, 2008
Grant Date -
Dec 15, 2005
app pub date -
Jul 8, 2005
filing date -
May 30, 2002
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
Oligonucleotides containing the non-palindromic sequence motif: X.sub.1X.sub.2X.sub.3X.sub.4X.sub.5X.sub.6X.sub.7X.sub.8, wherein X.sub.1 is C,T,G or A (preferably T or C); wherein X.sub.2 is C,T,G or A; wherein X.sub.7 is C,T,G or A (preferably G); at least three, and preferably all, of X.sub.3, X.sub.4, X.sub.5, X.sub.6 and X.sub.8 are T; and with the proviso that, in the motif, a C does not precede a G (in other terms, the nucleic acid motif does not consist of a CpG oligonucleotide), that modulate the immune response of animals of the order Primate, including humans, are disclosed. This immune modulation is characterized by stimulation of proliferation, differentiation, cytokine production and antibody production on B-cells and cell differentiation on plasmacytoid dendritic cells.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully