Method and apparatus for particle measurement employing optical imaging
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United States of America Patent
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May 27, 2008
Grant Date -
May 12, 2005
app pub date -
Nov 10, 2004
filing date -
Nov 10, 2003
priority date (Note) -
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Abstract
A system and method for measuring small particles suspended in a fluid are disclosed. The system employs optical imaging using diffraction enlargement. A sample of small particles illuminated by a light source is imaged onto a pixel array of detector elements using an imaging optical system having a reduced magnification not sufficient for forming a large enough image of a smallest particle of interest. A low-aperture imaging optics with NA<0.05 is used to add diffraction enlargement to the image corresponding to at least 5 pixels to enable accurate measurement of images of smallest particles of interest, and to increase an optical sampling volume. Suitably programmed processor is used for determining at least a pixel count for each of the diffraction-enlarged images, and for generating a number, size or distribution of particles accounting for pre-determined diffraction enlargement of particle images of different sizes. The method enables analysis of large samples of small particles in one measurement.

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- 15 United States
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Patent Owner(s)
Patent Owner | Address | |
---|---|---|
PROTEINSIMPLE | 3001 ORCHARD PARKWAY SAN JOSE CA 95134 |
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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King, Frederick David | Richmond, CA | 6 | 62 |
LeBlanc, Serge Emile | Ottawa, CA | 2 | 13 |
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Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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