Stabilized steroid composition and method for its preparation
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United States of America Patent
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May 27, 2008
Grant Date -
Aug 5, 2004
app pub date -
Jan 22, 2004
filing date -
Jan 23, 2003
priority date (Note) -
Expired
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Abstract
Stabilized 17-substituted hydrocortisone containing compositions and methods of manufacture. Isomerization of the hydrocortisone component of topical steroid compositions is markedly reduced by introducing an omega-6. acid in the form of linoleic acid into the skin preparation. Preferably, the linoleic acid is added as a component of refined safflower oil. The omega-6 acid has been found to be an effective way of preventing the isomerization of hydrocortisone 17-butyrate into the undesirable isomer HC21-B.
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