Pyridine substituted furan derivatives as Raf kinase inhibitors

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United States of America Patent

PATENT NO 7375105
APP PUB NO 20040248896A1
SERIAL NO

10488650

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Abstract

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Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH.sub.2 CO, S or NH, or the moiety X--R.sup.1 is hydrogen; Y.sub.1 and Y.sub.2 independently represent CH or N; Ar is a mono- or fused bicyclic aromatic or heteroaromatic group which may be optionally substituted; one of X.sub.1 and X.sub.2 is selected from O, S or NR.sup.11 and the other is CH, wherein R.sup.11 is hydrogen, C.sub.1-6alkyl, aryl or arylC.sub.1-6alkyl.

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Patent Owner(s)

Patent OwnerAddress
SMITHKLINE BEECHAM P L CNEW HORIZONS COURT BRENTFORD MIDDLESEX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dean, David Kenneth Harlow, GB 40 267
Takle, Andrew Kenneth Harlow, GB 27 171
Wilson, David Matthew Harlow, GB 52 269

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