Method for base sequencing and biologically active nucleic acids
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United States of America Patent
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May 20, 2008
Grant Date -
Jun 17, 2004
app pub date -
Nov 11, 2001
filing date -
Nov 28, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Aptamers are nucleic acids and similar molecules, such as peptide-nucleic acids, that specifically bind to a ligand such as a protein or peptide. The present invention provides aptamers comprising at least one base capable of base pairing and different from the standard Watson-Crick bases. The present invention also relates to a method for preparation of such aptamers and to methods for sequencing nucleic acids that comprise at least one base capable of base pairing and different from the standard Watson-Crick bases.
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