Methods of constructing camel antibody libraries
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United States of America Patent
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May 13, 2008
Grant Date -
Feb 17, 2005
app pub date -
Sep 13, 2002
filing date -
Sep 13, 2001
priority date (Note) -
Expired
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Abstract
The present invention provides camel antibody libraries that maintain in vivo diversity of camelid antibody variable region genes. The in vivo diversity of antibody variable region genes can be accomplished by, for example, mixing genes derived from a plurality of animals or modifying gene amplification conditions. Conventional methods yield only VHHs with limited repertoire diversity. However, the present invention provides libraries comprising genes encoding functional VHHs with sufficient repertoire size. According to the present invention, libraries that enable to freely obtain VHHs against arbitrary antigens are provided. VHHs have excellent solubility and stability, and show a reactivity that usually cannot be expected from tetrameric IgGs.
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