Avermectin aglycon synthase genes
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United States of America Patent
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May 13, 2008
Grant Date -
Jul 21, 2005
app pub date -
Dec 7, 2004
filing date -
Feb 24, 1999
priority date (Note) -
Expired
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Abstract
The present invention relates to an isolated DNA which comprises a DNA sequence encoding avermectin aglycon synthase domains that corresponds to multifunctional enzyme proteins involved in the biosynthesis of a polyketide compound, or its mutants having avermectin aglycon synthase activity, particularly functional modules and submodules in the DNA sequence derived from Streptomyces avermitilis, a polypeptide or mutants thereof encoded by the DNA or the mutants, a vector containing the DNA or the mutants, a host cell transformed with the DNA, the mutants thereof, or the vector, and a method for producing avermectin.
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