Methods of inhibiting .alpha..sub.v.beta..sub.3-mediated binding with .alpha..sub.v.beta..sub.3-specific antibodies
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United States of America Patent
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May 13, 2008
Grant Date -
Sep 4, 2003
app pub date -
Nov 25, 2002
filing date -
Jun 24, 1999
priority date (Note) -
Expired
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Abstract
The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to .alpha..sub.V.beta..sub.3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of .alpha..sub.V.beta..sub.3 by contacting .alpha..sub.V.beta..sub.3 with an enhanced LM609 grafted antibody.
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