Amide derivatives as NMDA receptor antagonists
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United States of America Patent
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Apr 29, 2008
Grant Date -
May 26, 2005
app pub date -
Dec 28, 2004
filing date -
Oct 24, 2000
priority date (Note) -
Expired
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Abstract
Compounds having NR2B selective NMDA receptor antagonist activity are disclosed of the formula (I) ##STR00001## wherein two of the neighboring R.sup.1, R.sup.2, R.sup.3 and R.sup.4 groups form an oxo-oxazolidine ring fused to the benzene ring of the indole nucleus, and the other two of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 groups are hydrogen atoms, R.sup.5 and R.sup.6 together with the nitrogen between them form a saturated or unsaturated, 4-6 membered heterocyclic ring, which is substituted by phenoxy, phenyl-(C.sub.1-C.sub.4 alkyl), phenyl-(C.sub.1-C.sub.4 alkoxy), phenoxy-(C.sub.1-C.sub.4 alkyl), or benzoyl, optionally substituted on the aromatic ring by one or more halogen atoms, cyano or hydroxy groups, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 alkoxy groups, X is NH--, Y is a --CH-- group, or pharmaceutically acceptable salts thereof formed with acids or bases.
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