Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies
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United States of America Patent
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Apr 29, 2008
Grant Date -
Feb 15, 2007
app pub date -
Sep 26, 2006
filing date -
Feb 12, 1999
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Abstract
The invention provides methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to inhibit angiogenesis in combination with a therapeutic amount of anti-tumor immunotherapeutic agent, such as a anti-tumor antigen antibody/cytokine fusion protein having a cytokine and a recombinant immunoglobulin polypeptide chain sufficient to elicit a cytokine-specific biological response.
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