Compounds with improved cartilage-inducing and/or bone-inducing activity
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United States of America Patent
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Apr 29, 2008
Grant Date -
Aug 4, 2005
app pub date -
Mar 16, 2005
filing date -
Nov 19, 1996
priority date (Note) -
Expired
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Abstract
The present invention concerns a bioactive implant material having a cartilage-inducing and/or bone-inducing activity composed of two components A and B, of which A is a bone-inducing and/or cartilage-inducing protein or protein mixture and preferably one or several proteins from the TGF-.beta. superfamily, preferably MP52 or a DNA sequence coding therefor and B is a carrier matrix composed of calcium phosphate ceramics with an interconnecting microporosity which already alone has bone-inducing properties. The invention additionally concerns the production of these compounds and their use for the treatment of diseases which affect cartilage and/or bones as well as to treat damage to cartilage and/or bone tissue.
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