Metastatic colon cancer specific promoter and uses thereof
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United States of America Patent
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Apr 29, 2008
Grant Date -
Jul 1, 2004
app pub date -
Jul 21, 2003
filing date -
Jul 22, 2002
priority date (Note) -
Expired
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Abstract
Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.
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