Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis

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United States of America Patent

PATENT NO 7361740
APP PUB NO 20050014934A1
SERIAL NO

10822300

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Abstract

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The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified antibody, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified antibody.

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Patent Owner(s)

Patent OwnerAddress
ABBOTT BIOTHERAPEUTICS CORP1500 SEAPORT BLVD REDWOOD CITY CA 94063

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hinton, Paul R Sunnyvale, CA 36 1611
Tso, J Yun Menlo Park, CA 71 1780
Tsurushita, Naoya Palo Alto, CA 64 1946
Vasquez, Maximiliano Palo Alto, CA 92 2096

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