Production of urokinase in a three-dimensional cell culture
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United States of America Patent
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Apr 22, 2008
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May 26, 2005
filing date -
May 26, 2004
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Abstract
Embodiments of a method for the production of human urokinase are disclosed. Also disclosed are embodiments of a cell culture well-suited for use with the disclosed method. The method involves culturing urokinase-producing cells, such as immortalized human renal cells, in a cell culture. The cell culture comprises microcarrier structures and a tissue culture medium. The urokinase production is allowed to occur while the cell culture remains relatively static, i.e., the cell culture is not substantially mixed.
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