Approach to molecular diagnosis of human papillomavirus-related diseases
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United States of America Patent
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Apr 22, 2008
Grant Date -
Oct 14, 2004
app pub date -
Apr 11, 2003
filing date -
Apr 11, 2003
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Abstract
The present invention relates to an accurate, sensitive, and efficient sequential or concurrently sequential method for molecular diagnosis of human papillomavirus (HPV)-based disease, where the method improves the accuracy and reliability of diagnostic and prognostic assessments of HPV-based disease. The method of the invention comprises a primary screen of a sample for HPV nucleic acids, followed by a secondary screen for molecular markers, such as proliferation and cell cycle control group protein markers. The sequential or concurrently sequential method significantly reduces the number of false positive results.
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