Assay for low molecular weight heparin
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United States of America Patent
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Apr 15, 2008
Grant Date -
Feb 19, 2004
app pub date -
Aug 16, 2002
filing date -
Aug 16, 2002
priority date (Note) -
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Abstract
A prothrombin time reagent for determination of low molecular weight heparin in frsh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture includes a phosphatidylalcohol. A formulation buffer which includes a sensitivity adjuster is used in formulating the reagent. The recombinant animal tissue factor includes rabbit brain. The synthetic phospholipids of the mixture include palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylserine (POPS), and a phosphatidylalcohol. The phosphatidyl alcohol includes dioleoylphosphatidylethanol, dioleoylphosphatidylmethanol, dioleoylphosphatidylpropanol, dioleoylphosphatidylbutanol, and dioleoylphosphatidylinositol. The sensitivity adjuster included in the formulation buffer is .gamma.-Cyclodextrin. The formulated reagent is air-dried and remains stable for at least 3 weeks at 37.degree. C.
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