Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
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United States of America Patent
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Apr 15, 2008
Grant Date -
Jul 11, 2002
app pub date -
Sep 17, 2001
filing date -
Oct 20, 1995
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Abstract
Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen. In particular, these molecular adjuvants are employed in compositions designed to deliver the specific immunogen to antigen presenting cells and simultaneously deliver signals to those cells that produce the desired immune response. Methods are also disclosed for delivery of these molecular adjuvants to patients, resulting in the transduction of activating signals to the targeted antigen presenting cell, thereby enhancing the immune response to the co-delivered immunogen.
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