Kits for measuring cellular transmembrane potential changes
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United States of America Patent
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Apr 15, 2008
Grant Date -
Jul 14, 2005
app pub date -
Dec 22, 2004
filing date -
Aug 8, 2001
priority date (Note) -
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Abstract
The invention encompasses kits for an improved method for measuring membrane potential using compounds of the formula I as potentiometric probes. These probes may be used in combination with other fluorescent indicators such as Indo-1, Fura-2, and Fluo-3, such probes may be used in microplate reading devices such as FLIPR.TM., fluorescent imaging plate reader, sold by Molecular Devices Corp., of Sunnyvale, Calif.; flow cytometers; and fluorometers. Such probes are used to measure membrane potential in live cells ##STR00001## wherein X is O or S; and n is 1 or 2.
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