Probing of specific nucleic acids
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United States of America Patent
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Apr 1, 2008
Grant Date -
Aug 1, 2002
app pub date -
Dec 31, 2001
filing date -
Apr 30, 1996
priority date (Note) -
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Abstract
The present invention relates to improved methods for probing of specific nucleic acids using circularizable probes designed such that they report the presence of a target sequence by allowing a detectable moiety to remain bound if an only if the probe has been cyclized in a target-dependent linking reaction. The invention may be used for distinction between sequence specific variations of nucleic acids.
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