Hemostatic soluble cellulose fibers containing coagulating protein for treating wound and process for producing the same

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United States of America Patent

PATENT NO 7351422
APP PUB NO 20020156498A1
SERIAL NO

10069561

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Abstract

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Proposed is a novel soluble trauma-healing and hemostatic cellulose fiber capable of absorbing and readily dissolving hemorrhaging trauma loci when applied thereto and of promoting the hemostatic action of blood platelets and fibrin and cell adhesion to the trauma site. The coagulation protein-containing soluble trauma-healing and hemostatic cellulose fiber is produced in that after treatment of a natural or regenerated cellulose fiber with an aqueous sodium hydroxide solution, said fiber is carboxymethylated by reaction with a monochloro acetic acid solution for a given time (hours) in such a manner that the degree of partial substitution of the glucose units constituting the cellulose molecule (etherification degree) is 0.5-less than 1.0% and that, furthermore, the coagulation proteins fibrinogen, thrombin, and coagulation factor XIII are imparted by surface application or chemical bonding.

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Patent Owner(s)

Patent OwnerAddress
HOGY MEDICAL CO LTDTOKYO 107-8615

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aoshima, Motonori Tokyo, JP 6 58
Inoue, Toshiki Tokyo, JP 17 65
Jo, Yoshio Tokyo, JP 4 57
Matsushita, Koichi Tokyo, JP 36 685
Tanabe, Koji Tokyo, JP 156 1103

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