Liquid chromatographic method and system

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United States of America Patent

PATENT NO 7351334
APP PUB NO 20070068230A1
SERIAL NO

11605666

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Abstract

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A chromatographic monitor includes an array of flow cells with individual light sensors that are collectively an array of photodiodes. The output from the photodiodes are multiplexed. To prevent losing information, the photodiodes are each connected to a different one of a plurality of inputs to the multiplexer through a corresponding one of a plurality of circuits that stores energy during the time the one inlet is not connected through the multiplexer to the signal processing circuitry that forms a part of an absorbance monitor. Preferably, the energy storing circuit is a non-switching circuit with low bandwidth and a flat-topped response to an impulse. This improves the signal to noise ratio. A one pole low pass filter with a (1-1/e) Dirac pulse fall time and equal to the multiplex entire cycle repeat time can perform this function and a one pole low pass filter provides satisfactory results. Still better results can be obtained from a three pole, one or two percent overshoot filter with combined minimum frequency bandwidth and fast rise time. A rise time equal to 1/2 the multiplex entire cycle.

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Patent Owner(s)

Patent OwnerAddress
TELEDYNE INSTRUMENTS INC1049 CAMINO DOS RIOS THOUSAND OAKS CA 91360

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allington, legal representative Robert W Lincoln, NE 1 1
Allington, Robert W Lincoln, NE 83 1645
Blakley, Scott L Omaha, NE 9 94
Davison, Dale A Greenwood, NE 32 356

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