Rifamycin analogs and uses thereof
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United States of America Patent
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Mar 11, 2008
Grant Date -
Feb 24, 2005
app pub date -
Aug 11, 2004
filing date -
Aug 22, 2003
priority date (Note) -
Expired
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Abstract
The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3'-hydroxy analogs, 4'- and/or 6' halo and/or alkoxy analogs, and various 5' substituents that incorporate a cyclic amine moiety.
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