Thiadiazoles AS CXC- and CC- chemokine receptor ligands
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United States of America Patent
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Mar 4, 2008
Grant Date -
Oct 5, 2006
app pub date -
Dec 16, 2004
filing date -
Dec 19, 2003
priority date (Note) -
Expired
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Abstract
Disclosed are novel compounds of the formula: ##STR00001## and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.
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