Intermediate for biotin and process for producing the same
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United States of America Patent
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Feb 26, 2008
Grant Date -
Feb 17, 2005
app pub date -
Dec 4, 2002
filing date -
Dec 4, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention is to provide a process for preparing a synthetic intermediate of biotin which is industrially advantageous, and discloses a process for preparing a compound represented by the formula (I): ##STR00001## wherein R.sup.1 and R.sup.2 may be the same or different from each other, and each represents hydrogen atom, a benzyl group which may have a substituent(s) on the benzene ring, a benzhydryl group which may have a substituent(s) on the benzen ring, or a trityl group which may have a substituent(s) on the benzene ring, R.sup.3 represents cyano group, carboxyl group, an alkoxycarbonyl group, an alkylthiocarbonyl group, or a carbamoyl group which may have a substituent, or a salt thereof which comprises subjecting a compound represented by the formula (II-a): ##STR00002## wherein the symbols have the same meanings as defined above, or a salt thereof to ring transformation.
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