Dissolution testing of solid dosage forms intended to be administered in the oral cavity
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United States of America Patent
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Feb 19, 2008
Grant Date -
Dec 28, 2006
app pub date -
Jun 22, 2005
filing date -
Jun 22, 2005
priority date (Note) -
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Abstract
The invention is a method and device for determining dissolution of a solid compound within the oral cavity. The device models dissolution within the oral cavity with a flow-through cell containing a solid compound and physiological amounts of simulated saliva. The device supplies and removes the simulated saliva at rates similar to production and loss of saliva within the oral cavity. The simulated saliva interaction with the solid compound mimics saliva interaction with a solid compound within the oral cavity. Dissolution of solid compound is determined from simulated saliva collected from the flow-through cell outflow.
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