Method for monitoring the production of biomolecule crystals
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United States of America Patent
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Feb 12, 2008
Grant Date -
Aug 11, 2005
app pub date -
Feb 7, 2005
filing date -
Feb 5, 2004
priority date (Note) -
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Abstract
The invention relates to a method for monitoring the production of macromolecule crystals containing at least one fluorescence emitter, comprising the following steps: a) a solution volume with dissolved macromolecules of a molecule species containing at least one fluorescence emitter is subjected to conditions, which cause the macromolecules to crystallize to macromolecule crystals or which are expected to cause the macromolecules to crystallize to macromolecule crystals, b) the solution volume of step a is irradiated with coherent light, and the light scattered by the macromolecule crystals is detected in at least one defined spatial angle range by means for the detection scattered light, c) before, simultaneously with or after step b, the solution volume is irradiated with a light source, the light emission of which is suitable for exciting the fluorescence emitter, and the fluorescence light is detected by means for the detection of fluorescence light, and to a device for carrying-out the method.
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