Eliciting HCV-specific antibodies
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United States of America Patent
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Feb 12, 2008
Grant Date -
Jan 3, 2002
app pub date -
Dec 1, 2000
filing date -
Dec 1, 1999
priority date (Note) -
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Abstract
Described herein is a method of eliciting antibodies and neutralizing of binding antibodies against a hepatitis C virus (HCV) E1E2 or E2 antigen using HCV E2 or HCV E1E2 polypeptides and/or HCV E2 or E1E2 polynucleotides. Elicitation of anti-E2 antibodies and anti-E2 NOB antibodies can be used, inter alia, to provide model systems to optimize anti-E2 antibody responses and/or anti-E2 NOB antibody responses to HCV and to provide prophylactic or therapeutic treatment against HCV infection.
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