Importance

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Abstract

A compound of formula (I): ##STR00001## or a salt, solvate and chemically protected form thereof, wherein: R.sup.5 is an optionally substituted C.sub.5-20 aryl or C.sub.4-20 alkyl group; A is selected from the group consisting of: ##STR00002## wherein X and Y are selected from the group consisting of: O and CR.sup.3; S and CR.sup.3; NH and CR.sup.3; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; R.sup.3 is selected from H, F, Cl and optionally substituted C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.5-7 aryl and C.sub.5-7 aryl-C.sub.1-4 alkyl groups; R.sup.4 is selected from H, F, Cl and optionally substituted C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.5-7 aryl and C.sub.5-7 aryl-C.sub.1-4 alkyl groups; R.sup.6 is selected from H, F, Cl and optionally substituted C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.5-7 aryl and C.sub.5-7 aryl-C.sub.1-4 alkyl groups; D is selected from: ##STR00003## B is selected from the group consisting of: ##STR00004## where R.sup.N' is selected from H and C.sub.1-4 alkyl; where one of R.sup.P3 and R.sup.P4 is --C.sub.m alkylene-R.sup.2 and the other of R.sup.P3 and R.sup.P4 is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally when R.sup.P3 is --C.sub.m alkylene-R.sup.2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R.sup.2 is tetrazol-5-yl, m+n may be 0; or where one of R.sup.P3 and R.sup.P4 is --O--CH.sub.2--R.sup.2, and the other of R.sup.P3 and R.sup.P4 is H, n is 0; R.sup.N is H or optionally substituted C.sub.1-4 alkyl; R.sup.2 is either: --CO.sub.2H (carboxy); --CONH.sub.2; --CH.sub.2--OH; or tetrazol-5-yl.

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First Claim