Compositions and methods for regulating bacterial pathogenesis
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United States of America Patent
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Feb 5, 2008
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app pub date -
Mar 10, 2003
filing date -
Dec 2, 1998
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Abstract
The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
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