Method of preparing poly(ADP-ribose) polymerases inhibitors
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United States of America Patent
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Jan 29, 2008
Grant Date -
Mar 23, 2006
app pub date -
Sep 21, 2005
filing date -
Sep 22, 2004
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Abstract
This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[-5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.
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