Fluorescent fiberoptic probe for tissue health discrimination
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United States of America Patent
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Dec 18, 2007
Grant Date -
Feb 24, 2005
app pub date -
Jul 19, 2004
filing date -
Jul 10, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.
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