Methods and compositions for treating hypercholesterolemia
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United States of America Patent
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Dec 18, 2007
Grant Date -
Apr 13, 2006
app pub date -
Sep 7, 2005
filing date -
Sep 7, 2004
priority date (Note) -
Expired
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Abstract
The present invention provides methods and compositions for treating hypercholesterolemia using therapeutic apoE proteins. A therapeutic apoE protein is a naturally-occurring apoE protein (e.g., apoE1, apoE2, apoE2*, apoE2**, apoE3, and apoE4) that has one or more amino acid substitutions in the carboxy-terminal region which, when administered to a mammal having hypercholesterolemia, reduces the plasma cholesterol levels without inducing hypertriglyceridemia. The invention also provides a method for reducing plasma cholesterol using low doses of naturally-occurring apoE proteins.
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