Advanced cell-transducing transport domain-target protein-transport domain fusion protein and uses thereof
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United States of America Patent
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Dec 11, 2007
Grant Date -
Jul 27, 2006
app pub date -
Mar 13, 2003
filing date -
Oct 31, 2002
priority date (Note) -
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Abstract
The present invention provides a fusion protein which delivers a functional protein or peptide into a cell at enhanced efficiency. The fusion protein of the present invention is a transduction domain-target protein-transduction domain fusion protein, wherein the transduction domain, which comprises 6-12 amino acid residues whose more than 3/4 consist of arginine or lysine residues, is covalently bonded to each of the amino- and carboxyl-terminal ends of the target protein. Green fluorescence protein and Cu/Zn-superoxide dismutate (SOD) are used as the target protein.
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