Competent bacteria
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United States of America Patent
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Dec 4, 2007
Grant Date -
Feb 10, 2005
app pub date -
Sep 5, 2003
filing date -
Sep 6, 2002
priority date (Note) -
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Abstract
The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation competence. Specific E. coli strains, having significantly reduced genome sizes, are disclosed which are highly transformation competent. A medium and methodology is taught which enables transformation efficiencies to be increased further.
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