Method for detecting target nucleotide sequences
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United States of America Patent
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Dec 4, 2007
Grant Date -
Sep 11, 2003
app pub date -
Dec 15, 2000
filing date -
Dec 16, 1999
priority date (Note) -
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Abstract
A method for detecting nucleic acids wherein the binding activity of a nucleic acid aptamer, which is formed by the hybridization of a target nucleotide sequence and a probe, is detected using the binding with a ligand as an index has been provided. Utilizing a structure such as the three-way junction, whose binding activity significantly changes depending on a mismatch of a single nucleotide, as the nucleic acid aptamer SNP can be detected.
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