Pyrazole derivatives, their preparation and their use in pharmaceuticals
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United States of America Patent
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Nov 27, 2007
Grant Date -
Aug 11, 2005
app pub date -
Apr 13, 2005
filing date -
Oct 6, 1997
priority date (Note) -
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Abstract
The present invention relates to pyrazole derivatives of the formula I, their preparation and their use in pharmaceuticals: ##STR00001## in which X, R.sup.1, R.sup.1a, R.sup.2, R.sup.3, R.sup.4 and n are as defined in the claims, which are useful pharmaceutically active compounds for the therapy and prophylaxis of illnesses, for example of cardiovascular diseases such as hypertension, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I are capable of modulating the body's production of cyclic guanosine monophosphate 'cGMP' and are generally suitable for the therapy and prophylaxis of illnesses which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the formula I, to their use for the therapy and prophylaxis of the abovementioned illnesses and for preparing pharmaceuticals for this purpose, and also to pharmaceutical preparations which comprise the compounds of the formula I.
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