Electronic systems and component devices for macroscopic and microscopic molecular biological reaction, analyses, and diagnostics
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United States of America Patent
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Nov 27, 2007
Grant Date -
Feb 3, 2005
app pub date -
Aug 23, 2004
filing date -
Sep 27, 2000
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Abstract
This invention pertains to the design, fabrication, and uses of an electronic system which can actively carry out and control multi-step and multiplex reactions in macroscopic or microscopic formats. In particular, these reactions include molecular biological reactions, such as nucleic acid hybridizations, nucleic acid amplification, sample preparation, antibody/antigen reactions, clinical diagnostics, combinatorial chemistry and selection, drug screening, oligonucleotide and nucleic acid synthesis, peptide synthesis, biopolymer synthesis, and catalytic reactions. A key feature of the present invention is the ability to control the localized concentration of two or more reaction-dependant molecules and their reaction environment in order to greatly enhance the rate and specificity of the molecular biological reaction.
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