Adhesion and sealing of tissue with compositions containing polyfunctional crosslinking agents and protein polymers
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United States of America Patent
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Nov 27, 2007
Grant Date -
Jun 5, 2003
app pub date -
Apr 5, 2002
filing date -
May 5, 1995
priority date (Note) -
Expired
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Abstract
Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue adhesives and sealants. Particularly, block copolymers of elastin and fibroin are employed having lysine substitutions in spaced apart units, where the amino group can be crosslinked using difunctional crosslinking agents.
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