Creation of variable length and sequence linker regions for dual-domain or multi-domain molecules
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United States of America Patent
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Nov 20, 2007
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N/A
app pub date -
Sep 22, 2000
filing date -
Sep 22, 2000
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Expired
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Abstract
Disclosed are methods and compositions for creating a DNA, RNA or protein molecule with two or more nucleic acid or polypeptide domains, respectively, joined by a linker region. These methods are used to generate random linker libraries of nucleic acids that encode dual-domain or multi-domain polypeptides. The linker regions are characterized by both length and sequence variability.
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