Bioactive medical films
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United States of America Patent
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Nov 20, 2007
Grant Date -
Aug 5, 2004
app pub date -
Oct 10, 2003
filing date -
Jul 31, 2001
priority date (Note) -
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Abstract
A wound dressing, method of making, and method of use, utilizing a polymeric film having complexed thereto by hydrophobic interaction a construct including a polyanion covalently bonded to a hydrophobic prosthetic moiety, with one or more bioactive molecules directly complexed to the polyanion. The polyanion may be heparin or a heparin-activity molecule. The prosthetic group may include a hydrophobic silyl-containing moiety. Bioactive molecules include adhesive molecules, growth factor molecules, and therapeutic molecules, including antibiotics.
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