MD-1 inhibitors as immune suppressants
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United States of America Patent
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Nov 6, 2007
Grant Date -
Jan 29, 2004
app pub date -
Mar 16, 2001
filing date -
Mar 17, 2000
priority date (Note) -
Expired
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Abstract
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an agent that inhibits MD-1 with or without an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of MD-1 or an agent that activates or stimulates MD-1.
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